Effective combination of minocycline and interferon-beta in a model of multiple sclerosis.
نویسندگان
چکیده
The objective of the current study was to investigate whether minocycline improves the effect of an existing multiple sclerosis (MS) medication, interferon-beta, on experimental autoimmune encephalomyelitis (EAE) in mice. When used at sub-optimal doses, neither medication affected EAE but their combination at these doses led to the significant alleviation of EAE disease severity scores and histological outcomes. In culture, the toxicity of T cells to neurons was alleviated by their prior exposure to minocycline or interferon-beta and their combination further attenuated neuronal death. Collectively, these results suggest the utility of the combination of minocycline and interferon-beta in MS.
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ورودعنوان ژورنال:
- Journal of neuroimmunology
دوره 165 1-2 شماره
صفحات -
تاریخ انتشار 2005